What Is dpDMC?

dpDMC (N-Dipropyl-Dimethocaine) is an orally active dopamine reuptake inhibitor (DRI) and a structural analog of DMC. Unlike DMC, which induces sedation at higher doses due to sodium channel blockade, dpDMC has been designed to maintain its dopaminergic effects while significantly reducing this side effect. Even repeated high dosages do not cause sedation or induce the ‘wired’ feeling associated with DMC. We selected dpDMC from a series of approximately 10 DMC analogs we synthesized.

ROA:

* Oral dosage: 100mg for mood elevation, to 250mg for deep euphoria and invigoration.

* Nasal absorption is inefficient; oral administration is recommended for optimal effectiveness.

* Duration: up to 3 hours

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Structure

The IUPAC of dpDMC is ‘3-(dipropylamino)-2,2-dimethylpropyl 4-aminobenzoate’, its CAS number is .

Product description

Tripreports:

https:/­/­old.reddit.com/­r/­researchchemicals/­comments/­1na293l/­­ndipropyldimethocainedpdmc_experimental_log/­
https:/­/­old.reddit.com/­r/­researchchemicals/­comments/­1na6q4t/­­report_of_oral_intake_of_dpdmc_instead_of_insuff/­

120 mg insufflated (…) Effects: task engagement improved; curiosity increased; mild euphoria. Tongue numbness; mood mildly elevated. suggests NE/­DA mediation. Hyperthermia detected. Absence of pronounced anxious edge. (…) NE-like stimulation (…) desire to redose.

It’s very good, but it shines on oral administration which i am currently writing the report.

Oral administration of capsule filled with 230mg N-Dipropyl-Dimethocaine (…) i feel great! pro-social activities are extremely rewarding.

~220mg (oral capsules) challenge under the same conditions (25mg Trimipramine) caused robust stimulation and sociability effect that lasted about 3 hours, unlike insuff. of dpDMC, oral administration does indeed cause cocaine-like sociability, and a great mood improvement, even like i said under the influence of a potent antipsychotic.

https:/­/­old.reddit.com/­r/­ResearchChemicalsNL/­comments/­1nkwbpi/­­anyone_that_has_tried_dpdmc_ndipropyldimethocaine/­

i love this … i enjoy it a lot, like all dopamineric stimulants. it’s a super deep relaxer at the end of the day and a super euphoriant.

https:/­/­katsulapharma.com/­dpDMC2.html

exhibits a stimulant profile with a notable NE/­DA component and mild peripheral anesthetic action. Stimulation lacks the high-anxiety signature commonly associated with potent noradrenergic agonists. (…) improved sociability and elevated mood (…) The compound feels like an improvement over dimethocaine; it lacks the pro-social punch of phenidates (e.g. methylphenidate, 4-MeTMP, 3-CMC). Its stimulation aligns more with NEP-like mechanisms than with classic cocaine-mimetics.

Empirical order (most to least cocaine-like) as reported:
Cocaine > 3-CMC > 4-MeTMP > dpDMC > dimethocaine > tetracaine > procaine > chloroprocaine